Publications

To view a full list of our publications on PubMed, click here.

Selected Publications  

  1. Rudak PT, Choi J, Parkins KM, Summers KL, Jackson DN, Foster PJ, Skaro AI, Leslie K, McAlister VC, Kuchroo VK, Inoue W, Lantz O, Haeryfar SMM: Chronic stress physically spares but functionally impairs innate-like invariant T cells. Cell Reports 2021, 35(2):108979. PMID: 33852855
  2. Choi J, Mele TS, Porcelli SA, Savage PB, Haeryfar SMM: Harnessing the versatility of invariant NKT cells in a stepwise approach to sepsis immunotherapy. The Journal of Immunology 2021, 206(2): 386-397. PMID: 33310870
  3. Rudak PT, Yao T, Richardson CD, Haeryfar SMM: Measles virus infects and programs MAIT cells for apoptosis. The Journal of Infectious Diseases 2021, 223(4): 667-672. PMID: 32623457
    • Featured in an invited live interview broadcast by Global News Radio 980 CFPL on December 23, 2020
    • Covered by London Free Press in an article entitled “Measles vaccine found to protect immune response” on December 30, 2020
    • Featured in the CIHR Institute of Infection and Immunity (III) E-Bulletin on June 3, 2021
  4. Haeryfar SMM: MAIT cells in COVID-19: heroes, villains, or both? Critical Reviews in Immunology 2020, 40(2) 173-184. PMID: 32749095
  5. Yao T, Shooshtari P, Haeryfar SMM: Leveraging public single-cell and bulk transcriptomic datasets to delineate MAIT cell roles and phenotypic characteristics in human malignancies. Frontiers in Immunology 2020, 11: 1691. PMID: 32849590
  6. Meilleur CE, Memarnejadian A, Shivji AN, Benoit JM, Tuffs SW, Mele TS, Singh B, Dikeakos JD, Topham DJ, Mu HH, Bennink JR, McCormick JK, Haeryfar SMM: Discordant Rearrangement of Primary and Anamnestic CD8+ T Cell Responses to Influenza A Viral Epitopes Upon Exposure to Bacterial Superantigens: Implications for Prophylactic Vaccination, Heterosubtypic Immunity and Superinfections. PLoS Pathogens 2020 May 20, 16(5):e1008393. [PMID: 32433711]
  7. Meilleur CE, Wardell CM, Mele TS, Dikeakos JD, Bennink JR, Mu HH, McCormick JK, Haeryfar SM: Bacterial superantigens expand and activate, rather than delete or incapacitate, preexisting antigen-specific memory CD8+ T Cells. The Journal of Infectious Diseases 2019, 219(8): 1307-1317 [PMID: 30418594]
  8. Memarnejadian A, Meilleur CE, Shaler CR, Khazaie K, Bennink JR, Schell TD, Haeryfar SM: PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination. The Journal of Immunology 2017, 199(9): 3348-3359 [PMID: 28939757]
  9. Shaler CR, Tun-Abraham ME, Skaro AI, Khazaie K, Corbett AJ, Mele T, Hernandez-Alejandro R, Haeryfar SM: Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment. Cancer Immunology, Immunotherapy 2017, 66(12): 1563-1575 [PMID: 28798979]
  10. Zeppa JJ, Kasper KJ, Mohorovic I, Mazzuca DM, Haeryfar SM, McCormick JK: Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive Vβ-specific T cells. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2017 [PMID: 28794279]
  11. Shaler CR, Choi J, Rudak PT, Memarnejadian A, Szabo PA, Tun-Abraham ME, Rossjohn J, Corbett AJ, McCluskey J, McCormick JK, Lantz O, Hernandez-Alejandro R, Haeryfar SM: MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: defining a novel mechanism of superantigen-induced immunopathology and immunosuppression. PLOS Biology 2017, 15(6): e2001930 [PMID:28632753]
  12. Szabo PA, Goswami A, Mazzuca DM, Kim K, O’Gorman DB, Hess DA, Welch ID, Young HA, Singh B, McCormick JK, Haeryfar SM: Rapid and rigorous IL-17A production by a distinct subpopulation of effector memory T lymphocytes constitutes a novel mechanism of toxic shock syndrome immunopathology. The Journal of Immunology 2017, 198(7): 2805-18 [PMID:28219889]
  13. Szabo PA, Rudak PT, Choi J, Xu SX, Schaub R, Singh B, McCormick JK, Haeryfar SM: Invariant NKT cells are pathogenic in the HLA-DR4-transgenic humanized mouse model of toxic shock syndrome and can be targeted to reduce morbidity. The Journal of Infectious Diseases 2017, 215(5): 824-9 [PMID:28035011]
  14. Szabo PA, Goswami A, Memarnejadian A, Mallett CL, Foster PJ, McCormick JK, Haeryfar SM: Swift intrahepatic accumulation of granulocytic myeloid-derived suppressor cells in a humanized mouse model of toxic shock syndrome. The Journal of Infectious Diseases 2016, 213(12): 1990-5 [PMID:26908735]
  15. Memarnejadian A, Meilleur CE, Mazzuca DM, Welch ID, Haeryfar SM: Quantification of alloantibody-mediated cytotoxicity in vivo. Transplantation 2016, 100(5): 1041-51 [PMID:26985743]
  16. Anantha RV, Mazzuca DM, Xu SX, Porcelli SA, Fraser DD, Martin CM, Welch I, Mele T, Haeryfar SM, McCormick JK: T helper type 2-polarized invariant natural killer T cells reduce disease severity in acute intra-abdominal sepsis. Clinical & Experimental Immunology 2014, 178(2): 292-309 [PMID:24965554]
  17. Kasper KJ, Zeppa JJ, Wakabayashi AT, Xu SX, Mazzuca DM, Welch I, Baroja ML, Kotb M, Cairns E, Cleary PP, Haeryfar SM, McCormick JK: Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC class II-dependent manner. PLoS Pathogens 2014, 10(5): e1004155 [PMID:24875883]
  18. Rytelewski M, Meilleur CE, Yekta MA, Szabo PA, Garg N, Schell TD, Jevnikar AM, Sharif S, Singh B, Haeryfar SM: Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS ONE 2014, 9(2): e90439 [PMID:24587363]
  19. Maleki Vareki S, Harding MJ, Waithman J, Zanker D, Shivji AN, Rytelewski M, Mazzuca DM, Yekta MA, Chen W, Schell TD, Haeryfar SM: Differential regulation of simultaneous antitumor and alloreactive CD8+ T-cell responses in the same host by rapamycin. American Journal of Transplantation 2012, 12(1): 233-9 [PMID:22026814]
  20. Hayworth JL, Mazzuca DM, Maleki Vareki S, Welch I, McCormick JK, Haeryfar SM: CD1d-independent activation of mouse and human iNKT cells by bacterial superantigens. Immunology and Cell Biology 2012, 90(7): 699-709 [PMID:22041925]
  21. Walker KM, Rytelewski M, Mazzuca DM, Meilleur SA, Mannik LA, Yue D, Brintnell WC, Welch I, Cairns E, Haeryfar SM: Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist. Immunology and Cell Biology 2012, 90(6): 630-9 [PMID:21912419]
  22. Mannik LA, Chin-Yee I, Sharif S, Van Kaer L, Delovitch TL, Haeryfar SM: Engagement of glycosylphosphatidylinositol-anchored proteins results in enhanced mouse and human invariant natural killer T cell responses. Immunology 2011, 132(3): 361-75 [PMID:21070234]
  23. Chau TA, McCully ML, Brintnell W, An G, Kasper KJ, Vines ED, Kubes P, Haeryfar SM, McCormick JK, Cairns E, Heinrichs DE, Madrenas J: Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nature Medicine 2009, 15(6): 641-8 [PMID:19465927]
  24. Haeryfar SM, Lan Z, Leon-Ponte M, Duffy KR, Ge W, Liu W, Mele T, Garcia B, Wang H*: Prolongation of cardiac allograft survival by rapamycin and the invariant natural killer T cell glycolipid agonist OCH. Transplantation 2008, 86(3): 460-68 [PMID:18698251]
  25. Haeryfar SM, Hickman HD, Irvine KR, Tscharke DC, Bennink JR, Yewdell JW*: Terminal deoxynucleotidyl transferase establishes and broadens anti-viral CD8+ T cell immunodominance hierarchies. The Journal of Immunology 2008, 181(1): 649-59 [PMID:18566432]
  26. Haeryfar SM: The importance of being a pDC in antiviral immunity: the IFN mission versus Ag presentation? Trends in Immunology 2005, 26(6): 311-7 (opinion article) [PMID:15922947]
  27. Yewdell JW and Haeryfar SM: Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design. Annual Review of Immunology 2005, 23: 651-82 [PMID:15771583]
  28. Haeryfar SM, DiPaolo RJ, Tscharke DC, Bennink JR, Yewdell JW: Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. The Journal of Immunology 2005, 174(6): 3344-51 [PMID: 15749866] 
  29. Tscharke DC, Karupiah G, Zhou J, Palmore T, Irvine KR, Haeryfar SM, Williams S, Sidney J, Sette A, Bennink JR, Yewdell JW: Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. The Journal of Experimental Medicine 2005, 201(1): 95-104 [PMID:15623576]
  30. Chen W, Masterman KA, Basta S, Haeryfar SM, Dimopoulos N, Knowles B, Bennink JR, Yewdell JW: Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon. European Journal of Immunology 2004, 34(1): 194-9 [PMID:14971045]
  31. Haeryfar SM, Al-Alwan MM, Mader JS, Rowden G, West KA, Hoskin DW: Thy-1 signaling in the context of costimulation provided by dendritic cells provides signal 1 for T cell proliferation and cytotoxic effector molecule expression, but fails to trigger delivery of the lethal hit. The Journal of Immunology 2003, 171(1): 69-77 [PMID:12816984]
  32. Al-Alwan MM, Liwski RS, Haeryfar SM, Baldridge WH, Hoskin DW, Rowden G, West KA: Cutting Edge: Dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent. The Journal of Immunology 2003, 171(9): 4479-83 [PMID:14568920]