To view more articles by Dr. Haeryfar on PubMed, click here.

Selected Publications  

  1. Meilleur CE, Wardell CM, Mele TS, Dikeakos JD, Bennink JR, Mu HH, McCormick JK, Haeryfar SM: Bacterial superantigens expand and activate, rather than delete or incapacitate, preexisting antigen-specific memory CD8+ T Cells. The Journal of Infectious Diseases 2019, 219(8): 1307-1317 [PMID: 30418594]
  2. Memarnejadian A, Meilleur CE, Shaler CR, Khazaie K, Bennink JR, Schell TD, Haeryfar SM: PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination. The Journal of Immunology 2017, 199(9): 3348-3359 [PMID: 28939757]
  3. Shaler CR, Tun-Abraham ME, Skaro AI, Khazaie K, Corbett AJ, Mele T, Hernandez-Alejandro R, Haeryfar SM: Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment. Cancer Immunology, Immunotherapy 2017, 66(12): 1563-1575 [PMID: 28798979]
  4. Zeppa JJ, Kasper KJ, Mohorovic I, Mazzuca DM, Haeryfar SM, McCormick JK: Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive Vβ-specific T cells. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2017 [PMID: 28794279]
  5. Shaler CR, Choi J, Rudak PT, Memarnejadian A, Szabo PA, Tun-Abraham ME, Rossjohn J, Corbett AJ, McCluskey J, McCormick JK, Lantz O, Hernandez-Alejandro R, Haeryfar SM: MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: defining a novel mechanism of superantigen-induced immunopathology and immunosuppression. PLOS Biology 2017, 15(6): e2001930 [PMID:28632753]
  6. Szabo PA, Goswami A, Mazzuca DM, Kim K, O’Gorman DB, Hess DA, Welch ID, Young HA, Singh B, McCormick JK, Haeryfar SM: Rapid and rigorous IL-17A production by a distinct subpopulation of effector memory T lymphocytes constitutes a novel mechanism of toxic shock syndrome immunopathology. The Journal of Immunology 2017, 198(7): 2805-18 [PMID:28219889]
  7. Szabo PA, Rudak PT, Choi J, Xu SX, Schaub R, Singh B, McCormick JK, Haeryfar SM: Invariant NKT cells are pathogenic in the HLA-DR4-transgenic humanized mouse model of toxic shock syndrome and can be targeted to reduce morbidity. The Journal of Infectious Diseases 2017, 215(5): 824-9 [PMID:28035011]
  8. Szabo PA, Goswami A, Memarnejadian A, Mallett CL, Foster PJ, McCormick JK, Haeryfar SM: Swift intrahepatic accumulation of granulocytic myeloid-derived suppressor cells in a humanized mouse model of toxic shock syndrome. The Journal of Infectious Diseases 2016, 213(12): 1990-5 [PMID:26908735]
  9. Memarnejadian A, Meilleur CE, Mazzuca DM, Welch ID, Haeryfar SM: Quantification of alloantibody-mediated cytotoxicity in vivo. Transplantation 2016, 100(5): 1041-51 [PMID:26985743]
  10. Anantha RV, Mazzuca DM, Xu SX, Porcelli SA, Fraser DD, Martin CM, Welch I, Mele T, Haeryfar SM, McCormick JK: T helper type 2-polarized invariant natural killer T cells reduce disease severity in acute intra-abdominal sepsis. Clinical & Experimental Immunology 2014, 178(2): 292-309 [PMID:24965554]
  11. Kasper KJ, Zeppa JJ, Wakabayashi AT, Xu SX, Mazzuca DM, Welch I, Baroja ML, Kotb M, Cairns E, Cleary PP, Haeryfar SM, McCormick JK: Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC class II-dependent manner. PLoS Pathogens 2014, 10(5): e1004155 [PMID:24875883]
  12. Rytelewski M, Meilleur CE, Yekta MA, Szabo PA, Garg N, Schell TD, Jevnikar AM, Sharif S, Singh B, Haeryfar SM: Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS ONE 2014, 9(2): e90439 [PMID:24587363]
  13. Maleki Vareki S, Harding MJ, Waithman J, Zanker D, Shivji AN, Rytelewski M, Mazzuca DM, Yekta MA, Chen W, Schell TD, Haeryfar SM: Differential regulation of simultaneous antitumor and alloreactive CD8+ T-cell responses in the same host by rapamycin. American Journal of Transplantation 2012, 12(1): 233-9 [PMID:22026814]
  14. Hayworth JL, Mazzuca DM, Maleki Vareki S, Welch I, McCormick JK, Haeryfar SM: CD1d-independent activation of mouse and human iNKT cells by bacterial superantigens. Immunology and Cell Biology 2012, 90(7): 699-709 [PMID:22041925]
  15. Walker KM, Rytelewski M, Mazzuca DM, Meilleur SA, Mannik LA, Yue D, Brintnell WC, Welch I, Cairns E, Haeryfar SM: Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist. Immunology and Cell Biology 2012, 90(6): 630-9 [PMID:21912419]
  16. Mannik LA, Chin-Yee I, Sharif S, Van Kaer L, Delovitch TL, Haeryfar SM: Engagement of glycosylphosphatidylinositol-anchored proteins results in enhanced mouse and human invariant natural killer T cell responses. Immunology 2011, 132(3): 361-75 [PMID:21070234]
  17. Chau TA, McCully ML, Brintnell W, An G, Kasper KJ, Vines ED, Kubes P, Haeryfar SM, McCormick JK, Cairns E, Heinrichs DE, Madrenas J: Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nature Medicine 2009, 15(6): 641-8 [PMID:19465927]
  18. Haeryfar SM, Lan Z, Leon-Ponte M, Duffy KR, Ge W, Liu W, Mele T, Garcia B, Wang H*: Prolongation of cardiac allograft survival by rapamycin and the invariant natural killer T cell glycolipid agonist OCH. Transplantation 2008, 86(3): 460-68 [PMID:18698251]
  19. Haeryfar SM, Hickman HD, Irvine KR, Tscharke DC, Bennink JR, Yewdell JW*: Terminal deoxynucleotidyl transferase establishes and broadens anti-viral CD8+ T cell immunodominance hierarchies. The Journal of Immunology 2008, 181(1): 649-59 [PMID:18566432]
  20. Haeryfar SM: The importance of being a pDC in antiviral immunity: the IFN mission versus Ag presentation? Trends in Immunology 2005, 26(6): 311-7 (opinion article) [PMID:15922947]
  21. Yewdell JW and Haeryfar SM: Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design. Annual Review of Immunology 2005, 23: 651-82 [PMID:15771583]
  22. Haeryfar SM, DiPaolo RJ, Tscharke DC, Bennink JR, Yewdell JW: Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. The Journal of Immunology 2005, 174(6): 3344-51 [PMID: 15749866
  23. Tscharke DC, Karupiah G, Zhou J, Palmore T, Irvine KR, Haeryfar SM, Williams S, Sidney J, Sette A, Bennink JR, Yewdell JW: Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. The Journal of Experimental Medicine 2005, 201(1): 95-104 [PMID:15623576]
  24. Chen W, Masterman KA, Basta S, Haeryfar SM, Dimopoulos N, Knowles B, Bennink JR, Yewdell JW: Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon. European Journal of Immunology 2004, 34(1): 194-9 [PMID:14971045]
  25. Haeryfar SM, Al-Alwan MM, Mader JS, Rowden G, West KA, Hoskin DW: Thy-1 signaling in the context of costimulation provided by dendritic cells provides signal 1 for T cell proliferation and cytotoxic effector molecule expression, but fails to trigger delivery of the lethal hit. The Journal of Immunology 2003, 171(1): 69-77 [PMID:12816984]
  26. Al-Alwan MM, Liwski RS, Haeryfar SM, Baldridge WH, Hoskin DW, Rowden G, West KA: Cutting Edge: Dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent. The Journal of Immunology 2003, 171(9): 4479-83 [PMID:14568920]